Therapeutic promise of Prunus laurocerasus compounds for cardiovascular disease and type 2 diabetes
DOI:
https://doi.org/10.66636/gmj.v1.i2.a120Keywords:
Prunus laurocerasus, cardiovascular disease, type 2 diabetes, antioxidant activity, polyphenols, Nrf2 pathway, NF-kappa B, waste valorization, nutraceuticalsAbstract
Background Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain leading drivers of global mortality and share a common pathological network of oxidative stress, chronic inflammation, and insulin resistance. Prunus laurocerasus L. (cherry laurel), an evergreen shrub indigenous to the Black Sea region, has emerged as a promising multi-target candidate by virtue of its phenolic acids, anthocyanins, and flavonoids.
Methods Phenolic acids, catechins, and anthocyanins were quantified in juice, dried fruit (35 °C drying), and processing residues of Georgian autochthonous cherry laurel using validated spectrophotometric methods. Antioxidant activity was assessed by the DPPH radical-scavenging assay and expressed as the IC50 (mg of sample required for 50 % inhibition).
Results Dried fruit contained the highest concentrations of total anthocyanins, catechins, and phenolic acids and showed the strongest antioxidant activity (IC50 = 1.98 ± 0.02 mg). Processing residues outperformed juice on antioxidant potency (IC50 = 3.23 ± 0.05 mg vs 5.05 ± 0.07 mg), indicating that a substantial fraction of the most active antioxidant compounds remains bound to skins and pulp residues after pressing.
Conclusion Georgian cherry laurel — and particularly its dried fruit and processing residues — represents a concentrated and effective substrate for the development of standardised antioxidant, antidiabetic, and cardioprotective preparations. The retention of significant bioactivity in waste fractions supports a circular-economy approach to nutraceutical development. Translation from bench to bedside will require standardised extracts and rigorous human clinical trials.
Keywords Prunus laurocerasus; cherry laurel; antioxidant activity; polyphenols; anthocyanins; catechins; type 2 diabetes; cardiovascular disease; metabolic syndrome; waste valorisation
References
1. Ahmed M. Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol. Immun Ageing. 2025;22(1):28. https://doi.org/10.1186/s12979-025-00378-0.
2. Alasalvar C, Pelvan E, Özdemir KS. Antioxidants, polyphenols, and health benefits of cherry laurel: a review. J Funct Biomater. 2020;11:28.
3. Chong B, Jayabaskaran J, Jauhari SM, Chan SP, Goh R, Kueh MTW, et al. Global burden of cardiovascular diseases: projections from 2025 to 2050. Eur J Prev Cardiol. 2025;32:1001–15. https://doi.org/10.1093/eurjpc/zwae281.
4. Yang H, Ma Q, Han L, Liu H. A global prediction of cardiovascular disease from 2020 to 2030. J Am Coll Cardiol. 2020.
5. Basirat R, Hosseini SA, Dehghan P, et al. Therapeutic effect of high-dose green tea extract on weight reduction: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2015;34(6):1208–14. https://doi.org/10.1016/j.clnu.2014.12.013.
6. Beyhan Ö, Aktaş M, Yilmaz N, Şimşek M, Gerçekçioğlu R. Determination of antioxidant activity, phenolic compounds and biochemical properties of cherry laurel (Laurocerasus officinalis R.) grown in Sakarya, Turkey. Erwerbs-Obstbau. 2018;60:87–94.
7. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol. 1995;28:25–30.
8. Cabrera C, Artacho R, Giménez R. Beneficial effects of green tea — a review. J Am Coll Nutr. 2006;25(2):79–99. https://doi.org/10.1080/07315724.2006.10719518.
9. Carvalho AC, Sousa RB, Franco-Duarte R, Fernandes E. Phenolic compounds from cherries and berries for chronic disease management and cardiovascular risk reduction. Nutrients. 2024;16(11):1597. https://doi.org/10.3390/nu16111597.
10. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. https://doi.org/10.1016/j.diabres.2019.107843.
11. Cırrık S, Kabartan E, Hacıoğlu G, Güleç Peker EG. The effects of Prunus laurocerasus fruit extract on oxidative and endoplasmic reticulum stress responses in doxorubicin-induced cardiac damage. J Acad Res Med. 2024;14(1):34–9.
12. Cırrık S, Nigiz M, Sayın F, Atamanalp M, Kocaman EM, Arslan H, et al. Antioxidant efficiency of Prunus laurocerasus L. fruit extract on doxorubicin-induced hepatic and renal damage. Indian J Exp Biol. 2024;62(2):133–40.
13. Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717–29. https://doi.org/10.1089/jmf.2016.3705.
14. Demir S, Turan I, Aliyazicioglu Y. Cytotoxic effect of Laurocerasus officinalis extract on human cancer cell lines. Marmara Pharm J. 2016;20(2):121–6. https://doi.org/10.12991/marupj.259889.
15. Ding Y, Morozova K, Scampicchio M, Ferrentino G. Dietary antioxidant anthocyanins mitigate type II diabetes through improving glycometabolism and insulin resistance. J Agric Food Chem. 2021;69(49):14920–31. https://doi.org/10.1021/acs.jafc.1c05630.
16. Giusti MM, Wrolstad RE. Anthocyanins: characterization and measurement with UV-visible spectroscopy. In: Wrolstad RE, editor. Current Protocols in Food Analytical Chemistry. New York: John Wiley & Sons; 2001.
17. Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92. https://doi.org/10.3390/foods6100092.
18. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes. 2009;33(9):956–61. https://doi.org/10.1038/ijo.2009.135.
19. Karahalil FY, Şahin H, Dülger B. Phenolic composition and antioxidant capacity of cherry laurel (Laurocerasus officinalis Roem.) sampled from Trabzon region, Turkey. Afr J Biotechnol. 2011;10(72):16293–9.
20. Karakaş D, Ari F, Ulukaya E. Laurocerasus officinalis fruit extract induces cell death through caspase-mediated apoptosis in gastric cancer cell lines. Turk J Biochem. 2021;46(1):79–88. https://doi.org/10.1515/tjb-2020-0378.
21. Kartal D, Civelek S, Palabiyik SS, Yigit F, Yalcin A, Uzun H. The effect of cherry laurel, rutin flavonoid and α-lipoic acid on streptozotocin and nicotinamide induced type 2 diabetic rats given metformin. Bratisl Lek Listy. 2025;126(1):3–11. https://doi.org/10.1007/s44411-025-00316-0.
22. Lee J, Durst RW, Wrolstad RE. Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method. J AOAC Int. 2005;88(5):1269–78.
23. Margalitadze E, Kezheradze I, Japaridze I, Vanidze M, Kalandia A. Study of secondary metabolites in Georgian endemic plant raw materials and processing residues using UPLC-PDA-MS methods. Eurasia Proc Sci Technol Eng Math. 2025;36:183–91. https://doi.org/10.55549/epstem.1170.
24. Mitea AC, Popa CV, Popescu MN, Dinischiotu A, Dumitrescu DE, Popescu I, et al. Therapeutic potential of Prunus species in gastrointestinal oncology. Cancers. 2025;17(6):938. https://doi.org/10.3390/cancers17060938.
25. Orhan N, Aslan M, Şüküroğlu M, Deliorman Orhan D. Hypoglycaemic effect of seed and fruit extracts of laurel cherry in different experimental models and chemical characterization of the seed extract. J Ethnopharmacol. 2015;165:264–70.
26. Bakir M, Geyikoglu F, Colak S, Turkez H, Bakir TO, Hosseinigouzdagani M. Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis. Arh Hig Rada Toksikol. 2020;71(3):222–30. https://doi.org/10.2478/aiht-2020-71-3412.
27. Stalikas CD. Extraction, separation, and detection methods for phenolic acids and flavonoids. J Sep Sci. 2007;30:3268–95.
28. Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on lifespan of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013;68(1):6–16. https://doi.org/10.1093/gerona/gls070.
29. Sun B, Ricardo-da-Silva JM, Spranger I. Critical factors of vanillin assay for catechins and proanthocyanidins. J Agric Food Chem. 1998;46(10):4267–74. https://doi.org/10.1021/jf980366j.
30. Todorova M, Trendafilova A, Vitkova A, Petrova M. Chemical characteristics and biological potential of Prunus laurocerasus fruits. Food Chem. 2020;321:126713.
31. Turan I, Dedeoğlu N, Aliyazicioğlu Y, Süleyman H. Investigating the effect of Prunus laurocerasus fruit extract in type II diabetes induced rats. Int J Pharmacol. 2013;9(6):373–8.
32. Turrini E, Ferruzzi L, Fimognari C. Possible effects of dietary anthocyanins on diabetes and insulin resistance. Curr Drug Targets. 2017;18(6):629–40.
33. Uslu H, Uslu GA. Evaluating the effects of Prunus laurocerasus seed, fruit and leaf extracts on hyperglycaemia, insulin sensitivity and antioxidative activities in experimental diabetes in rats. Thai J Vet Med. 2021;51(4):725–32.
34. Uslu H, Özkaraca M, Özdemir G, Karaman M. Hepatoprotective activity of Prunus laurocerasus fruit extract against 5-FU-induced liver injury and LC-MS/MS profiling. Chem Biodivers. 2025. https://doi.org/10.1002/cbdv.202500798.
35. Aydın S, Öztürk Y. Antiproliferative effect of cherry laurel. J Turk Chem Soc Sect A Chem. 2016;3(3):217–28. https://doi.org/10.18596/jotcsa.21204.
36. Yazici K, Kaynak L. An important genetic resource for Turkey: cherry laurel (Laurocerasus officinalis Roemer). Acta Hortic. 2011;890:267–72. https://doi.org/10.17660/actahortic.2011.890.37.
37. Yildiz E, Ozturk B, Ozkan Y, Yilmaz B. The main quality attributes of non-sprayed cherry laurel (Laurocerasus officinalis Roem.) genotypes. Genetika. 2014;46(1):129–36. https://doi.org/10.2298/gensr1401129y.
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