Angioplasty of Saphenous Vein Grafts After Coronary Artery Bypass Surgery: A Single-Center Retrospective Study with Literature Review

Authors

DOI:

https://doi.org/10.5281/zenodo.19136330

Keywords:

CABG, CORONARY ARTERY DISEASE, coronary artery bypass grafting, saphenous vein graft, percutaneous coronary intervention, angioplasty, distal embolization, embolic protection devices, drug-eluting stents, acute coronary syndrome

Abstract

In many patients undergoing coronary artery bypass graft surgery (CABG), venous saphenous grafts (SVG) are used in addition to arterial grafts. Treatment of degenerated and occluded venous grafts is complex and challenging. Angioplasty on occluded venous bypass grafts involves a high rate of complications (such as massive distal embolization).

Objectives:
To review the demographic data, risk factors, outcomes, and complications of SVG use in CABG surgery, and on this basis to build an algorithm for optimal treatment.

Methods:
A retrospective study of patients who underwent angioplasty of saphenous vein grafts (SVGs) between 2005 and 2015 in a tertiary care hospital. Patients were divided into two groups: 2005–2009 (group A) and 2010–2015 (group B), and the comparison was performed according to demographic data, risk factors, time from CABG, as well as angiographic features.

Results:
Among the 238 patients, 226 (95%) were male, with a mean age of 68±22 years.
74.4% suffered from hypertension, 56.3% from diabetes mellitus, 17.2% from chronic kidney disease, and 99% had a history of previous myocardial infarction.
62% of patients were admitted due to ACS.

Distal protection devices were used in only 31 (22%) patients.
Intervention was performed mainly on the right and circumflex coronary arteries.

A lower amount of contrast was used in group B (186 vs 137 mL, p=0.0018).
There was more frequent use of covered stents in group B (18.8% vs 2.1%, p=0.003), as well as increased use of protection devices (36.4% vs 9.5%, p=0.0002).

Conclusions:
The progression of technologies, mainly the use of protection devices, lowered the rate of complications during intervention on SVGs. This was also reflected in the reduced amount of contrast material used and lower incidence of kidney injury. Over the years, there has been a tendency to treat more severely ill patients with longer time since surgery (“older” grafts).

Keywords: coronary artery bypass grafting; saphenous vein graft; angioplasty; complications; distal embolization; protection devices; stents; acute coronary syndrome

References

1. Weintraub WS, Clements SD Jr, Crisco LV, Guyton RA, Craver JM, Jones EL, Hatcher CR Jr. Twenty-year survival after coronary artery surgery: An institutional perspective from Emory University. Circulation 2003;107:1271–7.

2. Peykar S, Angiolillo DJ, Bass TA, Costa MA. Saphenous vein graft disease. Minerva Cardioangiol 2004; 52:379–90.

3. Kostantinos M, Grines C, Bilodeau L. Current Percutaneous Treatment Strategies for Saphenous Vein Graft Disease. Catheterization and Cardiovascular Interventions, 2013, 82:406–13.

4. Brilakis ES, Wang TY, Rao SV, et al. Frequency and predictors of drug-eluting stent use in saphenous vein bypass graft percutaneous coronary interventions: A report from the American College of Cardiology, 2010; 3:1068–73.

5. Allen K, Cheng D, Cohn W, Connolly M, Edgerton J, Falk V, Martin J, Ohtsuka T, Vitali R. Endoscopic Vascular Harvest in Coronary Artery Bypass Grafting Surgery: a Consensus Statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). Innovations (Phila), 2005;1:51–60.

6. Björk VO, Ekeström S, Henze A, Ivert T, Landou C. Early and late patency of aortocoronary vein grafts. Thorac Cardiovasc Surg, 1981;15:11–21.

7. Cataldo G, Braga M, Pirotta N, Lavezzari M, Rovelli F, Marubini E. Factors influencing 1-year patency of coronary artery saphenous vein grafts. Circulation. 1993;88:93–8.

8. Roth JA, Cukingnan RA, Brown BG, Gocka E, Carey JS. Factors influencing patency of saphenous vein grafts. Ann Thorac Surg. 1979; 28:176–83.

9. Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ, Hooper GD, Burton JR. Coronary bypass graft fate and patient outcome: angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 patients during 25 years. J Am Coll Cardiol. 1996; 28:616–26.

10. Goldman S, Zadina K, Moritz T, Ovitt T, Sethi G, Copeland JG, Thottapurathu L, Krasnicka B, Ellis N. Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol. 2004; 44:2149–56.

11. Shah PJ, Gordon I, Fuller J, Seevanayagam S, Rosalion A, Tatoulis J, Raman JS, Buxton BF. Factors affecting saphenous vein graft patency: clinical and angiographic study in 1402 symptomatic patients operated on between 1977 and 1999. J Thorac Cardiovasc Surg. 2003; 126:1972–77.

12. Paz MA, Lupon J, Bosch X, Pomar JL, Sanz G. Predictors of early saphenous vein aortocoronary bypass graft occlusion. Ann Thorac Surg. 1993; 56:1101–06.

13. Goldman S, Copeland J, Moritz T, Henderson W, Zadina K, Ovitt T, Doherty J, Read R, Chesler E, Sako Y. Improvement in early saphenous vein graft patency after coronary artery bypass surgery with antiplatelet therapy: results of a Veterans Administration Cooperative Study. Circulation. 1988; 77:1324–32.

14. Gao G, Zheng Z. Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial. J Am Coll Cardiol. 2010; 56:1639–43.

15. Goldman S, Copeland J, Moritz T, Henderson W, Zadina K, Ovitt T, Kern KB, Sethi G, Sharma GV, Khuri S. Long-term graft patency (3 years) after coronary artery surgery. Effects of aspirin: results of a VA Cooperative study. Circulation. 1994; 89:1138–43.

16. Lytle BW, Loop FD, Taylor PC, Simpfendorfer C, Kramer JR, Ratliff NB, Goormastic M, Cosgrove DM. Vein graft disease: the clinical impact of stenoses in saphenous vein bypass grafts to coronary arteries. J Thorac Cardiovasc Surg. 1992; 103:831–40.

17. Lytle BW, Loop FD, Taylor PC, Goormastic M, Stewart RW, Novoa R, McCarthy P, Cosgrove DM. The effect of coronary reoperation on the survival of patients with stenoses in saphenous vein bypass grafts to coronary arteries. J Thorac Cardiovasc Surg. 1993; 105:605–12.

18. Kim FY, Marfeshka G, Ruggiero NJ, Adams S, Whellan DJ. Saphenous vein graft disease: review of pathophysiology, prevention, and treatment. Cardiol Rev, 2013 Mar-Apr; 21(2):101-9.

19. Brodie BR, Wilson H, Stuckey T, Nussbaum M, Laurent S, Brad¬shaw B, et al. Outcomes with drug-eluting versus bare-metal stents in saphenous vein graft intervention results from the STENT (strategic transcatheter evaluation of new therapies) group. JACC Cardiovasc Interv. 2009; 2(11):1105–12.

20. O'Connor GT, Malenka DJ, Quinton H, Robb JF, Kellett MA, Jr, Shu¬brooks S, et al. Multivariate prediction of in-hospital mortality after percutaneous coronary interventions in 1994-1996. North¬ern New England Cardiovascular Disease Study Group. J Am Coll Cardiol. 1999; 34(3):681–91.

21. Sdringola S, Assali AR, Ghani M, Moustapha A, Achour H, Yusuf SW, et al. Risk assessment of slow or no-reflow phenomenon in aortocoronary vein graft percutaneous intervention. Catheter Cardiovasc Interv. 2001;54(3):318–24.

22. Abbo KM, Dooris M, Glazier S, O'Neill WW, Byrd D, Grines CL, et al. Features and outcome of no-reflow after percutaneous coronary intervention. Am J Cardiol. 1995; 75(12):778–82.

23. Coolong A, Baim DS, Kuntz RE, O'Malley AJ, Marulkar S, Cutlip DE, et al. Saphenous vein graft stenting and major adverse car¬diac events: a predictive model derived from a pooled analysis of 3958 patients. Circulation. 2008; 117(6):790–7.

24. Al-Lamee R, Ielasi A, Latib A, Godino C, Ferraro M, Arioli F, et al. Clinical and angiographic outcomes after percutaneous recana¬lization of chronic total saphenous vein graft occlusion using modern techniques. Am J Cardiol. 2010; 106(12):1721–7.

25. Luca T, Bedogni F. Treatment of Saphenous Vein Graft Disease: “Never Ending Story” of the “Eternal Return”. Res Cardiovasc Med. 2014 August, 3(3): e21092.

26. Sadr-Ameli M, Mousavi H, Heidarali M, Maadani M, Ghelich Y, Ghadrdoost B. Early and Midterm Major Adverse Cardiac Events in Patient With Saphenous Vein Graft Using Direct Stenting or Embolic Protection Device Stenting. Res Cardiovasc Med. 2014 February; 3(1): e13012.

27. Kirtane AJ, Heyman ER, Metzger C, Breall JA, Carrozza JP. Corre¬lates of adverse events during saphenous vein graft intervention with distal embolic protection: a PRIDE substudy. JACC Cardio¬vasc Interv. 2008; 1(2):186–91.

28. Hong MK, Mehran R, Dangas G, Mintz GS, Lansky AJ, Pichard AD, et al. Creatine kinase-MB enzyme elevation following successful saphenous vein graft intervention is associated with late mortal¬ity. Circulation. 1999; 100(24):2400–5.

29. Cohen DJ, Murphy SA, Baim DS, Lavelle TA, Berezin RH, Cutlip DE, et al. Cost-effectiveness of distal embolic protection for pa¬tients undergoing percutaneous intervention of saphenous vein bypass grafts: results from the SAFER trial. J Am Coll Cardiol. 2004; 44(9):1801–8.

30. Baim DS, Wahr D, George B, Leon MB, Greenberg J, Cutlip DE, et al. Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts. Circulation. 2002; 105(11):1285–90.

31. Stone GW, Rogers C, Hermiller J, Feldman R, Hall P, Haber R, et al. Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts. Circulation. 2003; 108(5):548–53.

32. Mauri L, Rogers C, Baim DS. Devices for distal protection dur¬ing percutaneous coronary revascularization. Circulation. 2006; 113(22):2651–6.

33. Emmanouli S, Michael Lee, Mehili J. Saphenous Vein Graft Interventions. Current treatment options in Cardiovascular Medicine, March 2014, 16:301.

34. Lowell F. Satler, Do We Still Need Distal Protection in the Treatment of SVG Disease? Editorial Comment. Catheterization and Cardiovascular Interventions, 2008, 72:804–5.

35. Banerjee S, Brilakis ES, Embolic protection during saphenous vein graft interventions. Invasive Cardiol. 2009 Aug; 21(8):415-7.

36. Karakyriou M, Hadjimiltiades S, Meditskou S, Nenopoulou E, Efthimiadis G. Embolization after percutaneous coronary intervention in acute coronary syndrome. Herz 2015; 40:36–42.

37. Herrmann J . Peri-procedural myocardial in¬jury. Eur Heart J. 2005; 26(23): 2493–519.

38. Porto I, Cautilli G, Camaioni CL. Immediate evidence of the benefit of distal protection in vein graft intervention. J Cardiovasc Med. 2012; 13(12): 828–29.

39. El-Jack SS, Suwatchai P, Stewart JT. Dis¬tal embolization during native vessel and vein graft coronary intervention with a vascular protec¬tion device: predictors of high-risk lesions. J Interv Cardiol. 2007; 20(6):474–80.

40. Mehilli J, Pache J, Abdel-Wahab M, et al. Is drug-eluting-stenting associated with improved results in coronary artery bypass grafts? Drug-eluting versus bare-metal stents in saphenous vein graft lesions: A randomized controlled superiority trial. Lancet 2011; 378: 1071–8.

41. Brilakis ES, Lichtenwalter C, Abdel-karim AR. Continued benefit from paclitaxel-eluting compared with bare-metal stent implantation in saphenous vein graft lesions during long-term follow-up of the SOS (stenting of saphenous vein grafts) trial. JACC Cardiovasc Interv 2011;4:176–82.

42. Brennan J, Sketch H, David D, Trilesskaya M. Safety and clinical effectiveness of Drug-Eluting Stents for Saphenous Vein Graft Intervention in older individuals: Results From the Medicare-Linked National Cardiovascular Data Registry. Catheterization and Cardiovascular Interventions, 2015.

43. Vermeersch P, Agostoni P, Verheye S., DELAYED RRISC (Death Events at Long-term follow-up Analysis: Extended Duration of the Reduction of Restenosis in Saphenous Vein Grafts with Cypher Stent) Investigators. Increased late mortality after sirolimus-eluting stents versus bare-metal stents in diseased saphenous vein grafts: Results from the Randomized DELAYED RRISC Trial. J Am Coll Cardiol 2007; 50:261–7.

44. Aggarwal V, Stanislawski MA, Maddox TM, Nallamothu BK, Grunwald G, Adams JC. Safety and effectiveness of drug-eluting versus bare-metal stents in saphenous vein bypass graft percutaneous coronary interventions: insights from the Veterans Affairs CART program. J Am Coll Cardiol. 2014; 64(17):1825-36.

45. Hougaard M1, Thayssen P, Kaltoft A, Tilsted HH, Maeng M, Lassen JF, Thuesen L, Okkels Jensen L. Long-term outcome following percutaneous coronary intervention with drug-eluting stents compared with bare-metal stents in saphenous vein graft lesions: from Western Denmark Heart Registry. Catheter Cardiovasc Interv. 2014;83(7): 1035-42.

46. Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH. Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. Ann Surg. 2013 May;257(5): 824-33.

47. Savage MP, Douglas JS Jr, Fischman DL, et al. Stent placement compared with balloon angioplasty for obstructed coronary bypass grafts. Saphenous Vein De Novo Trial Investigators. N Engl J Med. 1997; 337(11):740-7.

48. Alam M, Bandeali SJ, Virani SS, et al. Clinical outcomes of percutaneous interventions in saphenous vein grafts using drug-eluting stents compared to bare-metal stents: a comprehensive meta-analysis of all randomized clinical trials. Clin Cardiol. 2012;35(5): 291-6.

49. Wiisanen ME, Abdel-Latif A, Mukherjee D, Ziada KM. Drug-eluting stents versus bare-metal stents in saphenous vein graft interventions: a systematic review and meta-analysis. JACC Cardiovasc Interv. 2010; 3(12):1262-73.

50. Lee MS, Yang T, Kandzari DE, Tobis JM, Liao H, Mahmud E. Comparison by meta-analysis of drug-eluting stents and bare metal stents for saphenous vein graft intervention. Am J Cardiol. 2010; 105(8):1076-82.

51. Brilakis ES, Papayannis AC, Abdel-Karim AR, et al. TCT abstract 219: prospective evaluation of the Xience V everolimus-eluting stent in saphenous vein graft atherosclerosis: the Xience V-SVG Angiographic Study. J Am Coll Cardiol. 2011; 58: B59.

52. Stankovic G, Colombo A, Presbitero P, et al. Randomized evaluation of polytetrafluoroethylene-covered stent in saphenous vein grafts (RECOVERS) trial. Circulation. 2003; 108(1):37-42.

53. Laarman GJ, Kiemeneij F, Mueller R, Guagliumi G, Cobaugh M, Serruys PW. Feasibility, safety, and preliminary efficacy of a novel ePTFE-covered self-expanding stent in saphenous vein graft lesions: the Symbiot II trial. Catheter Cardiovasc Interv. 2005; 64(3):361-8.

54. Turco MA, Buchbinder M, Popma JJ, et al. Pivotal, randomized U.S. study of the Symbiot covered stent system in patients with saphenous vein graft disease: eight-month angiographic and clinical results from the Symbiot III trial. Catheter Cardiovasc Interv. 2006; 68(3):379-88.

55. Abizaid A, Weiner B, Bailey SR, Londero H. Use of a self-expanding super-elastic all-metal endoprosthesis; to treat degenerated SVG lesions: the SESAME first in man trial. Catheter Cardiovasc Interv. 2010; 76(6):781-6.

56. Maia F, Costa JR Jr, Abizaid A, et al. Preliminary results of the INSPIRE trial with the novel MGuard stent system containing a protection net to prevent distal embolization. Catheter Cardiovasc Interv. 2010; 76(1):86-92.

57. Stone GW, Reifart NJ, Moussa I, et al. Percutaneous recanalization of chronically occluded coronary arteries: a consensus document: part II. Circulation. 2005; 112:2530.

58. Mautner SL, Mautner GC, Hunsberger SA, Roberts WC. Comparison of composition of atherosclerotic plaques in saphenous veins used as aortocoronary bypass conduits with plaques in native coronary arteries in the same men. Am J Cardiol. 1992; 70:1380.

59. Fischell TA, Subraya RG, Ashraf K, et al. "Pharmacologic" distal protection using prophylactic, intragraft nicardipine to prevent no-reflow and non-Q-wave myocardial infarction during elective saphenous vein graft intervention. J Invasive Cardiol. 2007; 19:58.

60. Levin T, Cutlip D. Coronary artery bypass graft surgery: Prevention and management of vein graft stenosis. Literature review, Uptodate. 2015.

61. Subramanian S, Sabik JF 3rd, Houghtaling PL. Decision-making for patients with patent left internal thoracic artery grafts to left anterior descending. Ann Thorac Surg. 2009; 87:1392.

62. Agostoni P, Vermeersch P, Semeraro O, Verheye S, Van Langenhove G, Van den Heuvel P, Convens C, Van den Branden F, Bruining N. Intravascular ultrasound comparison of sirolimus-eluting stent versus bare metal stent implantation in diseased saphenous vein grafts (from the RRISC [Reduction of Restenosis In Saphenous Vein Grafts With Cypher Sirolimus-Eluting Stent] trial). Am J Cardiol. 2007; 100:52–8.

63. Bhargava B, Kornowski R, Mehran R, Kent KM, Hong MK, Lansky AJ, Waksman R, Pichard AD, Satler LF, Leon MB. Procedural results and intermediate clinical outcomes after multiple saphenous vein graft stenting. J Am Coll Cardiol. 2000; 35:389–97.

64. Mathew V, Clavell AL, Lennon RJ, Grill DE, Holmes DR Jr. Percutaneous coronary interventions in patients with prior coronary artery bypass surgery: Changes in patient characteristics and outcome during two decades. Am J Med. 2000; 108:127–35.

65. Brener SJ, Ellis SG, Apperson-Hansen C, Leon MB, Topol EJ. Comparison of stenting and balloon angioplasty for narrowings in aortocoronary saphenous vein conduits in place for more than five years. Am J Cardiol. 1997; 79:13–8.

66. de Feyter PJ. Percutaneous treatment of saphenous vein bypass graft obstructions: A continuing obstinate problem. Circulation.2003; 107:2284–6.

67. Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: Executive summary: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheter Cardiovasc Interv. 2012; 79:453–95.

68. Drummer E, Furey K, Hollman J. Rupture of a saphenous vein bypass graft during coronary angioplasty. Br Heart J. 1987; 58:78–81.

69. Puri R, Dundon BK, Leong DP, Worthley SG, Worthley MI. Giant saphenous vein graft pseudoaneurysm rupture presenting with cardiac tamponade. Heart Lung Circ. 2009; 18:52–4.

70. Lowe R, Hammond C, Perry RA. Prior CABG does not prevent pericardial tamponade following saphenous vein graft perforation associated with angioplasty. Heart. 2005; 91:1052.

71. Zoghbi GJ, Goyal M, Hage F, Meyers RP, Papapietro SE, Brott BC, Misra VK, Iskandrian AE, Hillegass WB. Pretreatment with nitroprusside for microcirculatory protection in saphenous vein graft interventions. J Invasive Cardiol. 2009; 21:34–9.

72. Lee KW, Norell MS. Management of ‘no-reflow’ complicating reperfusion therapy. Acute Card Care. 2008; 10:5–14.

73. van Gaal WJ, Choudhury RP, Porto I, Channon K, Banning A, Dzavik V, Ramsamujh R, Bui S, Blackman DJ. Prediction of distal embolization during percutaneous coronary intervention in saphenous vein grafts. Am J Cardiol. 2007; 99:603–6.

74. Webb LA, Dixon SR, Safian RD, O’Neill WW. Usefulness of embolic protection devices during saphenous vein graft intervention in a nonselected population. J Interv Cardiol. 2005; 18:73–5.

75. Kaplan BM, Benzuly KH, Kinn JW, Bowers TR, Tilli FV, Grines CL, O’Neill WW, Safian RD. Treatment of no-reflow in degenerated saphenous vein graft interventions: Comparison of intracoronary verapamil and nitroglycerin. Cathet Cardiovasc Diagn. 1996; 39:113–8.

76. Stone GW, Rogers C, Hermiller J, et al. Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts. Circulation. 2003; 108:548–53.

77. Takahashi T, Anzai T, Yoshikawa T, Asakura Y, Ishikawa S, Mitamura H, et al. Absence of preinfarction angina is associated with a risk of no-reflow phenomenon after primary coronary angioplasty for a first anterior wall acute myocardial infarction. Int J Cardiol. 2000; 75:253–60.

78. Abbo KM, Dooris M, Glazier S, O’Neill WW, Byrd D, Grines CL, et al. Features and outcome of no-reflow after percutaneous coronary intervention. Am J Cardiol. 1995; 75:778–82.

79. Resnic FS, Wainstein M, Lee MK, Behrendt D, Wainstein RV, Ohno-Machado L, et al. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. Am Heart J. 2003; 145:42–6.

80. Galiuto L. Optimal therapeutic strategies in the setting of post-infarct no reflow: the need for a pathogenetic classification. Heart. 2004; 90:123–5.

81. Rezkalla SH, Kloner RA. No-reflow phenomenon. Circulation. 2002; 105:656–62.

82. Kaeng W, Norell M. Management of ‘no-reflow’ complicating reperfusion therapy. Acute Cardiac Care. 2008; 10: 5–14.

83. Klein LW, Kern MJ, Berger P, Sanborn T, Block P, Babb J, et al. Society of cardiac angiography and interventions: suggested management of the no-reflow phenomenon in the cardiac catheterization laboratory. Catheter Cardiovasc Interv. 2003; 60:194–201.

84. Wilson RF, Laxson DD, Lesser JR, White CW. Intense microvascular constriction after angioplasty of acute thrombotic coronary arterial lesions. Lancet. 1989; 1:807–11.

85. Kern MJ. Adenosine boluses: a cure for ‘no-reflow’? Cathet Cardiovasc Diagn. 1998; 45:366–7.

86. Granger CB. Adenosine for myocardial protection in acute myocardial infarction. Am J Cardiol. 1997; 79:44–8.

87. Micari A, Belcik TA, Balcells EA, Powers E, Wei K, Kaul S, et al. Improvement in microvascular reflow and reduction of infarct size with adenosine in patients undergoing primary coronary stenting. Am J Cardiol. 2005; 96:1410–5.

88. Michaels AD, Appleby M, Otten MH, Dauterman K, Ports TA, Chou TM, et al. Pretreatment with intragraft verapamil prior to percutaneous coronary intervention of saphenous vein graft lesions: results of the randomized, controlled vasodilator prevention on no-reflow (VAPOR) trial. J Invasive Cardiol. 2002; 14:299–302.

89. Werner GS, Lang K, Kuehnert H, Figulla HR. Intracoronary verapamil for reversal of no-reflow during coronary angioplasty for acute myocardial infarction. Catheter Cardiovasc Interv. 2002; 57:444–51.

90. Taniyama Y, Ito H, Morishita R, Ogihara T. Potential of microvascular reperfusion with adjunctive pharmacological intervention: its impact on myocardial perfusion and functional outcomes in patients with acute myocardial infarction. Drugs. 2001; 61:437–41.

91. Amit G, Cafri C, Yaroslavtsev S, Fuchs S, Paltiel O, Abu-Ful A, et al. Intracoronary nitroprusside for the prevention of the no-reflow phenomenon after primary percutaneous coronary intervention in acute myocardial infarction. A randomized, double-blind, placebo-controlled clinical trial. Am Heart J. 2006; 152:887–914.

92. Leal S, Teles R, Calé R, Sousa P, Brito J, Raposo L, Goncalves P. Percutaneous revascularization strategies in saphenous vein graft lesions: Long-term results. Rev Port Cardiol. 2012; 31(1):11-8.

93. Hiscock M, Oqueli E, Dick R. Percutaneous saphenous vein graft intervention - a review. Heart Lung Circ. 2007; 16:S,51-5.

94. Keeley E, Velez C, O’Neill W, et al. Long-term clinical outcome and predictors of major adverse cardiac events after percutaneous interventions on saphenous vein grafts. J Am Coll Cardiol. 2001; 38:659-65.

95. Sabik J, Blackstone E, Gillinov M, et al. Occurrence and risk factors for reintervention after coronary artery bypass grafting. Circulation. 2006; 114:454-60.

96. Pucelikova T, Mehran R, Kirtane A, et al. Short- and long term outcomes after stent-assisted percutaneous treatment of saphenous vein grafts in the drug-eluting stent era. Am J Cardiol. 2008; 101:63-8.

97. Meliga E, García-García H, Kukreja N, et al. Chronic total occlusion treatment in post-CABG patients: saphenous vein graft versus native vessel recanalization - long term follow up in the drug-eluting stent era. Catheter Cardiovasc Interv. 2007; 70:21-5.

98. Hoffmann R, Hamm C, Nienaber CA, et al. Implantation of sirolimus-eluting stents in saphenous vein grafts is associated with high clinical follow-up event rates compared with treatment of native vessels. Coron Artery Dis. 2007; 18: 559-64.

99. Hanekamp CE, Koolen JJ, Den Heijer P, et al. Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: The Venestent Study. Catheter Cardiovasc Interv. 2003; 60:452-7.

100. De Feyter PJ, van Suylen R, de Jaegere PP, et al. Balloon angioplasty for the treatment of lesions in saphenous vein bypass grafts. J Am Coll Cardiol. 1993; 21:15, 39-49.

101. Bansal D, Muppidi R, Singla S, et al. Percutaneous intervention on the saphenous vein bypass grafts - long-term outcomes. Catheter Cardiovasc Interv. 2008; 71:58-61.

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03/20/2026

How to Cite

Davarashvili, I., & Asher, E. (2026). Angioplasty of Saphenous Vein Grafts After Coronary Artery Bypass Surgery: A Single-Center Retrospective Study with Literature Review. Georgian Medical Journal, 1(1), 228–243. https://doi.org/10.5281/zenodo.19136330

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